Angioid streaks: Tiny breaks in the elastin-filled tissue in the back of the eye (retinae). These abnormalities are visible to the doctor during an examination using a viewing instrument called an ophthalmoscope. Angioid streaks are seen in patients with pseudoxanthoma elasticum (abbreviated PXE), a rare disorder of degeneration of the elastic fibers with tiny areas of calcification in the skin, back of the eyes (retinae), and blood vessels. Angioid streaks can be associated with blindness.