Syndrome, nervous colon: A common gastrointestinal disorder involving an abnormal condition of gut contractions (motility) characterized by abdominal pain, bloating, mucous in stools, and irregular bowel habits with alternating diarrhea and constipation, symptoms that tend to be chronic and to wax and wane over the years. Although the disorder can cause chronic recurrent discomfort, it does not lead to any serious organ problems.

Making the diagnosis usually involves excluding other illnesses. Treatment is directed toward relief of symptoms and includes changes in diet (eating high fiber and avoiding caffeine, milk products and sweeteners), exercise, relaxation techniques, and medications.

Alternative names include irritable bowel syndrome (IBS), spastic colitis, and mucus colitis.